The San Francisco 49ers had the worst rest advantage in the NFL last season, but that changed on their 2025 schedule.

The San Francisco 49ers are working to complete the sale of a 6.2% ownership stake in the team to three Bay Area families, a source told ESPN's Nick

The San Francisco 49ers are working to complete the sale of a 6.2% ownership stake in the team to three Bay Area families, a source told ESPN's Nick Wagoner on Thursday.

Veteran offensive lineman DJ Humphries, 31, and the 49ers agreed to terms on a contract according to an April 29 tweet from his agency, AMDG Sports. Now NBC Sports Bay Area's Matt Maiocco is reporting Humphries and the 49ers don't have a contract in place.

Taking a closer look at the San Francisco 49ers 2025 regular season schedule, highlighting must-watch matchups, reacting to the viral schedule release video, and sharing key updates from rookie minicamp.

The San Francisco 49ers are projected to finish with a winning record in 2025, which could mean a return to the playoffs.

The owners of the San Francisco 49ers are reportedly selling about 6% of the team to a trio of tech investing stalwarts, including billionaire Vinod Khosla.

The primetime schedule starts with the nearly annual night game against the Los Angeles Rams on Thursday night in Week 5. The 2025 season marks the sixth time in the last seven seasons that the 49ers’ rivalry will be renewed in primetime, with San Francisco dominating Los Angeles with a 4-1 record in those five games.