Underscoring the entire schedule is that the 2025 campaign will be the last in their longtime home of Highmark Stadium, where they began playing in 1973. As their new stadium across the street is scheduled to be ready for the 2026 season, the Bills have one final chance to chase Super Bowl glory in their farewell season to their 53-year home.

As part of their 2025 NFL schedule, the Buffalo Bills have what is expected to be a challenging matchup against the Baltimore Ravens on Sept. 7. You can see the Bills' full schedule below. Looking for additional details on the Buffalo Bills' 2025 results and NFL schedule? We've got you covered in the piece below.

Ahead of the Buffalo Bills learning their 2025 NFL schedule this week, here are some predictions and analysis for their season.