Meteorologists with the NWS Paducah office have also confirmed several tornadoes in its region the afternoon and evening of May 16. Three tornadoes impacted western Kentucky, including an EF-3 tornado in Morganfield with winds of 155 mph, an EF-2 tornado in Allegre and an EF-2 tornado in Casky.

Newlyweds Amerah and James Taylor lost their first home when a tornado struck London, Kentucky on 17 May. "We should not have survived this", Amerah Taylor said. The couple described being tossed around the house as the tornado struck and losing both of their wedding rings.

Tornadoes in southeastern Kentucky resulted in at least 19 confirmed fatalities, with a potential for a higher death toll. While Louisville experienced tree damage and power outages, no life-threatening injuries were reported.