Following an offseason of significant roster turnover, the San Francisco 49ers are hoping for improved results now that they know what their 2025 schedule looks like.

The calendar says “May 14.” When it says “September 7,” the San Francisco 49ers will be in Seattle. The 2025 NFL schedule was revealed on Wednesday, and the 49ers will begin the year on the road for the fourth time in five seasons.

NFL season will be here before you know it. After an offseason of roster turnover, the 49ers are preparing to embark on a potential transition season as they look to get younger — and cheaper — on both sides of the ball.

The San Francisco 49ers' 2025 schedule was released along with the rest of the NFL slate Wednesday. The 49ers will open the season against the division-rival Seattle Seahawks. Based on last season's results,

The San Francisco 49ers 2025 schedule has a ton of interesting wrinkles as they look to carve their route back to the NFL playoffs.

San Francisco is looking to contend again in the NFC West in 2025. Here's everything you need to know about their schedule.